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Results for
every body.

Our patented Tixel® technology is setting a new tone. Proven, precise, and brings results to every skin type.

Book a demo

A new energy in medical energy devices

Tixel is the next generation of energy-based devices. The world's first Thermo Mechanical Action (TMA®) brings safe, easy, and cost-effective treatments for skin rejuvenation and dry eye care.

Learn about our technology

Explore Tixel Solutions

Dry Eye

Gentle, non-invasive treatments for dry eye disease. A safe 2-minute treatment helps restore tears and comfort for months. Easy to use and fits seamlessly into every eye care practice.

Explore Dry Eye products
Tixel i device for dry eye treatment
Skin Rejuvenation

Tixel applies pure and precise heat energy to smoothen and tighten skin. Incredible versatility brings results quickly to all skin types and treatment areas. With minimal pain and downtime, it leverages our skin's natural rejuvenation powers.

Explore Aesthetics products
Tixel 2 device for skin rejuvenation

Experts trust it, patients swear by it

“You're going to find that there's so much of a demand for Tixel, that you're better off having one in each location.”

Dr. April Jasper, O.D.

USA

“I like to sleep good at night. I don't like to think about possible complications for my patients. So this is one of the things that's easy for me because it's very safe. And the downtime issue is also very selling. With just a simple Tixel treatment, then the downtime is really small, and then after the weekend they're back at home... at work.”

Dr. Ehud Reich, M.D.

Israel

“The Thermo-Mechanical Action of Tixel definitely enhances delivery of topicals by creating channels in the stratum corneum with minimal denaturation of the viable epidermis and dermis. The tissue is dry due to evaporation. Adding a topical creates this concentration gradient, driving forces of diffusion inside the dermis. We can see the enhanced uptake and PpIX fluorescence after pre-treatment with the Tixel device.”

Dr. Christine Dierickx, M.D.

Luxembourg

“Using Tixel provides me with a real-life, efficient solution where patients are very satisfied. And the device's mobility allows me to buy a single machine treat patients with it in all my clinics.”

Dr. Ehud Reich, M.D.

Israel

“The results are really obtained with minimal side effects and very short downtime. And thus, I think they are associated with high satisfaction rates of the patients.”

Prof. Assi Levi, M.D.

Israel

“One patient actually has an amusing anecdote... Following treatment, his wife said that her husband's skin feels elastic and smooth, and she was so happy with his outcome that she asked to participate in the study as well.”

Prof. Assi Levi, M.D.

Israel

“For me, Tixel is the future of skin resurfacing - safe, effective and delegable.”

Dr. Francesco Lino, M.D.

Italy

“Our Tixel device has been one of the best services we’ve offered in our 18 years of being open. The results are real, the technology is safe and easy to use, and the customer support has been impeccable.”

Kimberly Hutchinson

SkinFuzion • USA

“What sets Tixel i apart from other dry eye treatments is that it only takes 2 minutes for both eyes to be treated. Unlike older technology, Tixel i safely treats upper and lower eyelids to maximize improvement.”

Dr. Cynthia Matossian, M.D.

USA

“Tixel i is perfect for our low vision patients. It's quick, easy, and finally gave us a way forward after hitting so many walls. ”

Dr. Lauren Bailey, O.D.

USA

“In 40 years of practice, this is the most impressive treatment I've ever seen for Meibomian Gland Dysfunction. After 2 Tixel i treatments, I no longer need punctal plugs or drops.”

Dr. Debra Koloms, M.D.

USA

“I am blown away by the results. I haven't seen anything like this in over a decade. Our patients are happier than our cataract patients, that's a very high bar and Tixel blew right past that!”

Dr. Neil Notaroberto M.D.

USA

“What I like about Tixel is that you can get nice results without being aggressive. Patients can still do their daily activities.”

Dr. Kateryn Perez Willis, M.D.

Peru

“Patients are very happy because these are the lines that traditionally you have to do more invasive treatments: ablative treatments, non-ablative laser treatments. But they're getting very little downtime and getting a lot of improvement.”

Dr. Jordan V. Wang, M.D., MBE, MBA

USA

“Tixel is my primary modality for periorbital rejuvenation, as it enhances skin texture and quality and generates controlled micro-channels for optimized drug delivery, allowing for a truly safe and comprehensive treatment strategy.”

Dr. Guy Erlich, M.D. MSc

Israel

“I've been using this Tixel device now for the past year or so. One of the best devices I ever bought - fantastic results!”

Dr. Tapan Patel

UK

“First of all, patient satisfaction is huge. And the clinical results, as evidenced by the pictures that I've seen so far, look great.”

Dr. Eric Bernstein, M.D.

USA

“We're getting fantastic, noticeable results, the patients love the results. So yes, we're very pleased and would definitely, highly recommend Tixel.”

Dr. Claire Oliver, BDS

UK

“One of the things I've really liked about Tixel is the ease of use. It's a simple treatment really that my therapists can undertake with a little bit of training, and a treatment that's pretty comfortable for patients with a little bit of local anesthetic. And the results from treatment have been quite outstanding really, and certainly comparable in my eyes to other more aggressive treatments such as CO2 laser.”

Dr. Ian Strawford, M.D.

UK

“Tixel i is great because it allows us to have a first-line treatment for dry eye that allows patients to not be so dependent on eye drops and allows them to get a quick, effective, and efficient treatment in a short time that is really effective at controlling dry eye long term.”

Dr. Anders Hansson, O.D.

USA

“Honestly, Tixel i has exceeded our expectations. We knew the clinical data was solid, but sometimes the real-world implementation falls short, but our patients have been overwhelmingly positive in their feedback.”

Dr. Evan Shields, O.D.

USA

“There are limitations to radiofrequency and IPL, so we couldn't treat everyone. But Tixel i kind of opens up the door and lets us treat basically anyone who's struggling with dry eye”

Dr. Evan Shields, O.D.

USA

“Tixel can be used on all skin types and does not use lasers, radiation, or intense pulse light, giving this treatment has an excellent safety profile.”

Dr. Lauren Foley O.D

USA

“One of the early things that I'm seeing with Tixel is that patients feel better immediately, and this is really powerful because a lot of times we recommend at-home treatments that take two and three months to really help”

Dr. Brandon Wally O.D

USA

“Patients love Tixel for a number of reasons. In that, it is minimally invasive with very little pain when doing the procedure. There is also minimal downtime. And last of all, it's affordable to patients.”

Dr. Vernon Ching, M.D.

South Africa

“Once I choose my parameters, I will go and do my Tixel, of course. And once I have done the whole face, I will take advantage of my beautiful micropores that I have done, and I will put a solution on after.”

Dr. Kateryn Perez Willis, M.D.

Peru

Our Products

Thoughtfully designed for saftey and effective results in your practice.

Tixel i

2-Minute Dry-Eye Treatments.

Tixel i freestanding device

Tixel 2

Dual-Handpiece Time-Saving Versatility for Aesthetics.

Tixel 2 freestanding device

Tixel C

All-In-One, Compact Skin Rejuvenation.

Tixel C freestanding device

Battle tested, peer-reviewed

Tixel is loved by patients and providers around the world, and we have the science to prove it.

Peer-Reviewed Paper

The Efficacy of Thermal Mechanical Fractional Injury System for Facial Rejuvenation: Subjective, Objective and Image Analysis Study

February 24, 2025

PubMed

Guy Erlich, Ron Skorochod, Edmond Sabo, Rishi Saigal, Eliran Dahan, Yoram Wolf

Peer-Reviewed Paper

Safety and Effectiveness of a Thermo-Mechanical Fractional System at Low Settings for the Treatment of Photodamage

February 10, 2025

PubMed

Eric F Bernstein, Maggie Wang, Jennifer Wang, J Lee Pannell

Peer-Reviewed Paper

Percutaneous Delivery of Liquid Tetracycline Using a Thermal Resurfacing Drug Delivery System for the Treatment of Festoons

April 11, 2024

PubMed

Margarita Safir, Inbar Waizer, Ari Safir, Morris E Hartstein, Ofir Artzi

Peer-Reviewed Paper

Thermomechanical Fractional Injury Therapy Delivers Satisfactory Results, Less Pain With Surface Anesthesia

April 30, 2024

Medscape

Richard Mark Kirkner

Peer-Reviewed Paper

Frontal Fibrosing Alopecia-Related Facial Papules Successfully Treated With a Thermomechanical Fractional Injury Device

April 18, 2024

PubMed

Taciana Dal'Forno, Martina Souilljee Birck

Peer-Reviewed Paper

Effectiveness and Safety of a Thermo-Mechanical Action Device Versus Thermal Pulsation Device in the Treatment of Meibomian Gland Dysfunction

April 18, 2024

PubMed

E Sadri, A Verachtert, G D Parkhurst, J Echegoyen, I Klein, Y G Agmon, G J Berdy

Peer-Reviewed Paper

Safety and Efficacy of a Thermomechanical Fractional Injury Device for Periorbital Rhytides

February 22, 2023

PubMed

Jordan V Wang, Shirin Bajaj, David Orbuch, Moshe Lapidoth, Ifat Klein, Yael Agmon Gerste

Peer-Reviewed Paper

Prospective Evaluation of the Safety and Efficacy of Thermomechanical Fractional Injury for Perioral Rhytides

March 16, 2023

PubMed

Jordan V Wang, Shirin Bajaj, Alexa Steuer, David Orbuch, Roy G Geronemus

Peer-Reviewed Paper

Comprehensive Review of Thermomechanical Fractional Injury Device: Applications in Medical and Cosmetic Dermatology

February 17, 2024

PubMed

Blanca Estupiñan, Adam Souchik, Alexandra Kiszluk, Shraddha Desai

Peer-Reviewed Paper

Impact of Thermo-Mechanical Skin Treatment on Refraction and Keratometry in Patients with Dry Eye Disease and the Implications for Cataract Surgery

April 8, 2024

PubMed

Marta Blanco-Vázquez, Raquel Gil-Cazorla, Ankur Barua, Mukesh Taneja, Ludger Hanneken, Sunil Shah

Peer-Reviewed Paper

The Effect of Non-Ablative Thermomechanical Skin Treatment (Tixel®) on Dry Eye Disease: A Prospective Two-Centre Open-Label Trial

January 10, 2023

PubMed

Sunil Shah, Debarun Dutta, Ankur Barua, Ludger Hanneken, Shehzad A Naroo

Peer-Reviewed Paper

The Effect of Thermo-Mechanical Device (Tixel) Treatment on Evaporative Dry Eye Disease: A Pilot Prospective Clinical Trial

July 18, 2022

PubMed

M Safir, I Hecht, A Ahimor, S Zmujack-Yehiam, R Stein, E Bakshi, A Einan-Lifshitz 2, M E Hartstein

Peer-Reviewed Paper

Efficacy and Safety of a Thermal Fractional Skin Rejuvenation System (Tixel) for the Treatment of Facial and/or Scalp Actinic Keratoses

April 12, 2022

PubMed

Shabtai, Sloutsky, Lapidoth, Mimouni, Chorny, Snast, Leshem, Friedland, Hodak, Klein, Agmon, Levi

Peer-Reviewed Paper

Efficacy and safety of thermomechanical fractional injury‐assisted corticosteroid delivery versus intralesional corticosteroid injection for the tre..

December 16, 2021

PubMed

W Manuskiatti, C Yan, O Artzi, M K R Gervasio, R Wanitphakdeedecha

Peer-Reviewed Paper

Retrospective Study on the Safety and Tolerability of Clinical Treatments with a Novel Thermomechanical Ablation Device on 150 Patients

June 6, 2021

PubMed

Harryono Judodihardjo, Sajjad Rajpar

Peer-Reviewed Paper

Treatment of Periorbital Wrinkles Using Thermo-Mechanical Fractional Injury Therapy Versus Fractional Non-Ablative 1565 nm Laser: A Comparative Study

November 17, 2021

PubMed

Fares Salameh, Danny Daniely, Arielle Kauvar, Rafael L Carasso, Joseph N Mehrabi, Ofir Artzi

Peer-Reviewed Paper

Thermo‐Mechanical Fractional Injury Therapy for Facial Skin Rejuvenation in Skin Types II to V: A Retrospective Double‐Center Chart Review

March 2, 2020

PubMed

Danny Daniely, Harryono Judodihardjo, Sajjad F Rajpar, Joseph N Mehrabi, Ofir Artzi

Peer-Reviewed Paper

Thermo‐Mechanical Fractional Injury Enhances Skin Surface‐ and Epidermis‐ Protoporphyrin IX Fluorescence: Comparison of 5‐Aminolevulinic Acid ..

October 1, 2020

PubMed

C Foged, M Haedersdal, L Bik, C Dierickx, P A Phillipsen, K Togsverd-Bo

Peer-Reviewed Paper

Wound Healing Process After Thermomechanical Skin Ablation

January 13, 2020

PubMed

G Kokolakis, L von Grawert, M Ulrich, J Lademann, T Zuberbier, M Hofmann

Peer-Reviewed Paper

Enhanced Percutaneous Delivery of Beta-Blockers Using Thermal Resurfacing Drug Delivery System for Topical Treatment of Infantile Hemangiomas

July 10, 2020

PubMed

Jacob Mashiah, Efrat Bar-Ilan, Amir Koren, Or Friedman, Eyal Zur, Ofir Artzi

Peer-Reviewed Paper

Thermomechanical Ablation-Assisted Photodynamic Therapy for the Treatment of Acne Vulgaris. A Retrospective Chart Review of 30 Patients

April 9, 2020

PubMed

Y Hilerowicz, O Friedman, E Zur, R Ziv, A Koren, F Salameh, J N Mehrabi, O Artzi

Peer-Reviewed Paper

An Enhanced Transcutaneous Delivery of Botulinum Toxin for the Treatment of Hailey-Hailey Disease

December 27, 2019

PubMed

Efrat Bar-Ilan, Amir Koren, Wasim Shehadeh, Jacob Mashiah, Eli Sprecher, Ofir Artzi

Peer-Reviewed Paper

A New Method for Percutaneous Drug Delivery by Thermo-Mechanical Fractional Injury

June 28, 2019

PubMed

Ronen Shavit, Christine Dierickx

Peer-Reviewed Paper

A New Approach in the Treatment of Pediatric Hypertrophic Burn Scars: Tixel-Associated Topical Triamcinolone Acetonide and 5-Fluorouracil Delivery

January 20, 2020

PubMed

Ofir Artzi, Amir Koren, Roni Niv, Joseph N Mehrabi, Jacob Mashiah, Or Friedman

Peer-Reviewed Paper

The Scar Bane, Without the Pain: A New Approach in the Treatment of Elevated Scars: Thermomechanical Delivery of Topical Triamcinolone Acetonide and 5..

April 30, 2019

PubMed

Ofir Artzi, Amir Koren, Roni Niv, Joseph N. Mehrabi, Or Friedman

Peer-Reviewed Paper

Treatment of Port Wine Stain with Tixel-Induced Rapamycin Delivery Following Pulsed Dye Laser Application

December 4, 2019

PubMed

Ofir Artzi, Jos N. Mehrabi, Lee Heyman, Or Friedman, Jacob Mashiah

Peer-Reviewed Paper

The Toxic Edge: A Novel Treatment for Refractory Erythema and Flushing of Rosacea

October 12, 2018

PubMed

Or Friedman, Amir Koren, Roni Niv, Joseph N. Mehrabi, Ofir Artzi

Peer-Reviewed Paper

A Novel Thermo-Mechanical System Enhanced Transdermal Delivery of Hydrophilic Active Agents by Fractional Ablation

June 29, 2019

PubMed

Amnon C. Sintov, Maja A. Hofmann

Peer-Reviewed Paper

Fractional Treatment of Aging Skin with Tixel: A Clinical and Histological Evaluation

January 20, 2016

PubMed

Monica Elman, Nathalie Fournier, Gilbert Barnéon, Eric F. Bernstein, Gary Lask

Peer-Reviewed Paper

Fractional Vaporization of Tissue with an Oscillatory Array of High Temperature Rods: Part I: Ex Vivo Study

October 14, 2012

PubMed

Gary Lask, Monica Elman, Nathalie Fournier, Michael Slatkine

Read our studies

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Medical innovation that leads the industry in safe results and patient satisfaction.

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Discover Tixel® powered by TMA® technology. Revolutionary fractional skin resurfacing with maximum safety, minimal side effects. Quick, effective treatments for aesthetic and dry eye applications.

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